Treatment of 3-month-old male C57Bl/6 knockout (AdipoKO) and wild-type (WT) mice with GT extract reduced body weight, adiposity index, adipocyte size, and insulin resistance while reversing consequences of obesity in WT mice; however, the extract was ineffective in reverting these indicators in the AdipoKO mice. The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.