Results: According to the multivariate regression analysis, the predictors of impaired outcomes in COVID-19 patients are age (p < 0.001; OR 1.134; 95% HR 1.062–1.211), C reactive protein level (CRP) (p = 0.043; OR 1.006; 95% 1.000–1.013), invasive mechanical ventilation (IMV) (p < 0.001; OR 58.72; 95% HR 13.784–254.189), pulmonary embolism (PE) (p = 0.025; OR 3.718; 95% HR 1.183–11.681), and hospitalization in ICU (p = 0.012; OR 9.673; 95% 1.660–56.363). This evidence concerns the gene CRP and COVID-19.