Our study confirms that the production of proinflammatory cytokines such as TNF-α, IL-1 and IL-6 is induced when C. trachomatis invades the host reproductive system because the main goal of the immune system is to induce or enhance inflammation against chlamydia [118], then inhibit the growth of these microorganisms and control the infection, as well as prevent or slow down the formation of chlamydial lesions. This evidence concerns the gene IL1B and chlamydia trachomatis infectious disease.