TNF and heart failure: These studies have demonstrated that inflammatory biomarkers such as C-reactive protein [21], tumor necrosis factor-alpha (TNF-α) [22], interleukin (IL)-6 [23], lymphocyte, neutrophil, monocyte, and platelet counts [6,7], NLR [8], and SII [9] are associated with short- and long-term prognosis in heart failure.