Interestingly, in the subgroup without hypogonadism, total testosterone averaged 18.08 nmol/L versus 6.36 nmol/L in hypogonadal patients, while LH levels were significantly lower (7.35 vs. 14.37 IU/L), supporting an intact hypothalamic–pituitary–gonadal axis in the former group. Here, PLOD1 is linked to hypogonadism.