SCLC-A (ASCL1-dominant): Characterized by high expression of Achaete-Scute Family BHLH Transcription Factor 1 (ASCL1), this subtype is associated with classic neuroendocrine features and may be sensitive to B-Cell Lymphoma 2 (BCL-2) inhibition due to its dependency on anti-apoptotic pathways. Here, ASCL1 is linked to small cell lung carcinoma.