BRG1 is one of two mutually exclusive ATPases that are responsible for the ATP-dependent activity of SWI/SNF, but the second ATPase, SMARCA2, is not expressed in these cancers [12] making loss of BRG1 in SCCOHT sufficient to impair SWI/SNF-mediated tumor suppression. The gene discussed is SMARCA1; the disease is neoplasm.