By binding to integrin and CD44 receptors and activating WNK-1 (lysine deficient protein kinase 1), PRAS40 (proline-rich AKT substrate 40), and other signaling pathways, OPN can increase angiogenesis in breast and in liver cancer by triggering the αvβ3-NF-κB signaling pathway. This evidence concerns the gene WNK1 and liver cancer.