Cancer antigen 125 (CA125), B, alpha-fetoprotein, inhibin, carcinoembryonic antigen (CEA), squamous cell carcinoma antigen, carbohydrate antigen 19-9 (CA19-9), cancer antigen 27-29, human epididymis protein 4 (HE4), transthyretin, immunosuppressive acidic protein, leptin, cancer antigen 15-3 (CA15-3), cytokeratin 19, and thymidine kinase are also frequently studied as biomarkers for gynecological cancers. The gene discussed is LEP; the disease is female reproductive organ cancer.