Alternatively, given AMACR’s key role in the metabolism of BCFAs and bile acids [85], and the fact that some of these metabolites are high-affinity ligands for multiple orphan nuclear receptors (e.g., androstane receptor, pregnane X receptor, farnesoid X receptor, and peroxisome proliferator-activated receptors) that are implicated in cancer [115,116], increased AMACR activity may also modulate PCa cell growth through nuclear receptor signaling pathways. This evidence concerns the gene ESRRB and cancer.