SOD1 and neoplasm: BT-1, a dual inhibitor of SOD1 and CAT, increased intracellular ROS and superoxide anion levels, resulting in cell cycle arrest, apoptosis, and reduced tumor growth in DU145 xenografts, while the irreversible CAT inhibitor 3-amino-1,2,4-triazole (3-AT) elevated ROS levels without affecting superoxide radicals [162].