HAO1 and prostate adenocarcinoma: Notably, the mRNA expression of genes involved in peroxisomal H2O2 production—such as ACOX2, pipecolic acid oxidase (PIPOX), and hydroxyacid oxidase 1 (HAO1)—as well as those regulating the CoASH/acyl-CoA ratio, including ACOT8 and SLC25A17 (also known as PMP34, a peroxisomal transporter of nicotinamide adenine dinucleotide (NAD+), flavin adenine dinucleotide (FAD), and free CoASH [181]), is altered in prostate adenocarcinoma compared to normal prostate tissue (Figure 1C).