CRP and Decreased total neutrophil count: Özdemir et al. (2019) [39] reported that serial CRP measurements (cutoffs: Day 1 = 2.5 mg/dL, Day 2 = 4 mg/dL, Day 7 = 7 mg/dL) effectively distinguished culture-positive from culture-negative febrile neutropenia episodes (p < 0.05 for all days), with AUCs ranging from 0.742 to 0.807.