CRP and bacterial infectious disease with sepsis: These findings were significantly expanded by Kitanovski et al. (2006) [11], who demonstrated that IL-6 > 235.1 pg/mL on Day 1 had superior diagnostic accuracy for bacteremia/clinical sepsis (AUC = 0.867, sensitivity 87.5%, specificity 86.0%, NPV 95.6%) compared to CRP (AUC = 0.649, p < 0.05), though its utility diminished by Day 3 (AUC = 0.789).