CALCA and bacterial infectious disease with sepsis: Indeed, reported IL-10 cutoffs in pediatric FN range widely—from 4.37 pg/mL to 100 pg/mL—with lower thresholds (e.g., 4.37 pg/mL) favoring sensitivity for bacteremia detection when combined with PCT, and higher thresholds (e.g., 100 pg/mL) offering better specificity for severe infections.