IL-6 (AUC = 0.87), IL-8 (AUC = 0.86), and IL-10 (AUC = 0.83) demonstrated superior diagnostic performance as sepsis discriminators, unlike TNF-α, which showed no significant differences between groups (p = 0.16), with rapid declines by Day 3 (p < 0.005). Here, IL6 is linked to Sepsis.