IL10 and Shock: While TNF-α levels were significantly higher in bloodstream infections (median: 2.7 vs. 2.3 pg/mL; p < 0.001) and septic shock (3.0 vs. 2.3 pg/mL; p < 0.001), its diagnostic performance remained poor (AUC = 0.651, 95% CI: 0.594–0.707 for septic shock), vastly inferior to IL-6 (AUC = 0.888, 95% CI: 0.861–0.914) and IL-10 (AUC = 0.866, 95% CI: 0.828–0.903).