CXCL8 and bacterial infectious disease with sepsis: Doerflinger et al. (2021) [16] confirmed this narrative in a prospective analysis of 79 pediatric FN episodes, finding no significant difference in IL-8 levels between bacteremia (optimal ROC-derived cutoff >665.5 pg/mL) and non-bacteremia cases (AUC 0.666, p = 0.127).