NPM1 and anaplastic large cell lymphoma: Anaplastic large cell lymphoma (ALCL) is a rare disease accounting for 10–15% of the pediatric and 2% of adult non-Hodgkin lymphomas (NHLs), typically harboring the translocation t(2;5)(p23;q35) joining the tyrosine kinase anaplastic lymphoma kinase domain (ALK) to the nucleophosmin domain (NPM) located on chromosome 5q35 [1].