ACVR1 and central nervous system cancer: Other pHGG subtypes include those that are ACVR1-mutant, histone wild-type, such as pleomorphic xanthoastrocytoma (PXA)-like gliomas enriched with BRAF mutations, and NF1-associated gliomas with receptor tyrosine kinase fusions (Table 1) [42,98,99,100,101].