The elevation of PRX3 protein levels was further observed in the blood serum of IPMN patients, which is considered a precancerous condition and is characterized by growth within the pancreatic ducts, mucinous epithelial cells, and genetic alterations in KRAS and guanine nucleotide-binding protein and alpha-stimulating activity polypeptide (GNAS) [20]. Here, GNAS is linked to pancreatic intraductal papillary-mucinous neoplasm.