In Experiment 2, 36 PDAC, 10 IPMN, and 5 control subjects were subjected to blood serum analyses for the evaluation of the PRX3 protein via ELISA, and PRX3, Nrf2, CD44v9, FOXO3a, and p62 mRNA from EVs were evaluated using RT-PCR. The gene discussed is FOXO3; the disease is pancreatic intraductal papillary-mucinous neoplasm.