MAPK8 and cancer: Next, we examined the expression of oxidative-stress-resistance-related proteins, including PRX3, phospho (P)-Nrf2 (S40), p62, P-FOXO3a (S574; activated by JNK), P-FOXO3a (S7; activated by p38/ERK), and P-FOXO3a (S253; activated by AKT) via IHC in serial sections or using double IHC and compared their expression in PDAC cancer tissues to assess the role of PRX3 in the regulation of intracellular oxidative stress (Figure 2C).