BRCA2 and breast cancer: Using an arbitrary cut-off (fold change (FC) ≥ 2) and a statistically significant difference (p < 0.01), as described in the graphical abstract, we identified 11 upregulated and 44 downregulated transcripts in BRCA1-mut breast cancer, and 10 upregulated and 57 downregulated transcripts in BRCA2-mut breast cancer.