Furthermore, similar to the methylation-based smoking signature, our biometric analysis of DNA methylation chip data revealed three candidate loci in the CGI located upstream of the LINC00404 and LINC00403 genes, the cg02742906, cg15415452, and cg13692446 sites, which show an association between methylation and the status of distant metastasis in RCC. This evidence concerns the gene LINC00404 and renal cell carcinoma.