Furthermore, it has been reported that the PTENP1 pseudogene in RCC exhibits epigenetic silencing of pseudogene expression, and that the tumor suppressor lncRNAs MEG3 and LOC554202 show loss of expression as a result of aberrant promoter methylation and are associated with cancer cell invasiveness (ibid). The gene discussed is PTENP1; the disease is renal cell adenocarcinoma.