CD4 and neoplasm: Additionally, in a cohort of 543 LUAD patients, with 96 (17.6%) patients harbouring KEAP1 mutations, Cheng et al. [70] showed that six immune cell types, including CD8+ T cells, CD4+ T cells, B cells, macrophages, dendritic cells, and neutrophils, showed markedly lower infiltration levels in KEAP1-mutant tumours as compared to KEAP1 wild types [70].