Hypertension can be induced or exacerbated by taxanes, alkylating agents, Vascular Endothelial Growth Factor inhibitors, Poly(ADP-ribose) polymerase inhibitors, endocrine therapies (aromatase inhibitors, selective estrogen receptor modulators), estrogen receptor downregulators, sequential or combination therapy (aromatase inhibitors plus CDK inhibitor) and left-sided radiotherapy [19,65,66]. Here, ESR1 is linked to Hypertension.