Remarkably, the RBM17 located loop anchor is associated with instructive interactions involving other loop anchors within and upstream of IL2RA, specific for Lupus Erythematosus Systemic (SLE), Rheumatoid Arthritis (MTX), Relapsing Remitting Multiple Sclerosis (MSRR) and response to immune checkpoint inhibitor treatment (PD-1) (Figure 5). Here, RBM17 is linked to multiple sclerosis.