SOCS3 and pachyonychia congenita: Wu et al. report that adipose-derived MSC (AMSC) derived EVs deliver NEAT1 to PC cells, NEAT1 regulates the expression of Snail and SOCS3 in PC cells by competitive binding to miR-491-5p, which promotes the proliferation, migration, and gemcitabine resistance of PC cells and enhances tumorigenicity in vivo [101].