PEComas are characterized by the immunoexpression, among others, of both melanocytic markers (HMB-45, Melan-A, MiTF, and PNL2) and myoid markers (desmin, smooth muscle actin, muscle-specific actin, myosin, and calponin). The gene discussed is PMEL; the disease is neoplasm with perivascular epithelioid cell differentiation.