We have also highlighted the impact of miR-195-5p on the desmosomal complex, identifying a novel interaction between miR-195-5p and PNN, a desmosome-associated protein that plays a critical role in CRC development, which was able to enhance the strength of cellular adhesive junctions through the upregulation of KRT8 and KRT19 [21]. This evidence concerns the gene KRT19 and colorectal carcinoma.