VHL and von Hippel-Lindau disease: In all patients with informative INT2GRATE variants (i.e., Positive or Negative), the clinical data was consistent with their INT2GRATE status, demonstrating the application of INT2GRATE in offering insights into the role of the germline VHL variants in relation to VHL syndrome in each patient (Supplementary Materials Tables S4–S6, Online INT2GRATE Portal).