The genes related to VHL differential disorders include FH, FLCN, MET, BAP1, SDHA, SDHB, SDHC, SDHD, SDHAF2, TMEM127, MAX, RET, and NF1, which are collectively associated with an increased risk of pheochromocytoma, paraganglioma, and renal cell carcinoma (RCC) including ccRCC. This evidence concerns the gene SDHB and hereditary clear cell renal cell carcinoma.