IKZF2 and non-small cell lung carcinoma: Similarly, miR-192-5p enhances Treg differentiation through the RB1/NF-κBp65 signaling axis, reinforcing IL-10 secretion and immune suppression [40], while miR-4772-3p upregulates Helios (IKZF2), promoting Treg proliferation in NSCLC [108].