In hepatocellular carcinoma (HCC), HBV-driven tumors suppress miR-200c via TGF-β/STAT3 signaling, which in turn elevates PD-L1, while reintroduction of miR-200c reduces PD-L1 expression and reinvigorates T cells [107]. This evidence concerns the gene TGFB1 and hepatocellular carcinoma.