F2RL1 and neoplasm: Our, recent work (IJMS 2025) demonstrated the power of nutraceuticals to interfere with pro-tumor inflammatory signaling: oleocanthal, a phenolic compound from extra-virgin olive oil, was shown to selectively modulate the PAR-2 (protease-activated receptor-2) pathway in CRC cells, resulting in attenuation of TNF-α secretion and restoration of calcium homeostasis [441,442].