PTGS2 and colorectal carcinoma: Beyond statins, other drugs are on the radar for repurposing in CRC: metformin (an antidiabetic) has been shown to inhibit CRC stem cell growth by affecting AMPK/mTOR signaling, and aspirin (a traditional NSAID) is known to prevent CRC partly by blocking COX-2 mediated prostaglandin E2 production.