A recent analysis of laryngeal squamous cell carcinoma by single-cell RNA sequencing uncovered that this type of CSC exhibits high expression of stem cell marker genes such as CD133, ALDH1A1, and SOX4, and increased activity of tumor-related signaling pathways such as hypoxia, Wnt/β-catenin, and Notch [3]. Here, ALDH1A1 is linked to neoplasm.