MRC1 and colorectal carcinoma: In multivariable competing risk regression, age 65 years or older at the time of index CRC diagnosis (SHR = 3.04, 95% CI: 1.57–5.95), male sex (SHR = 1.75, 95% CI: 1.01–3.019), stages I or II at the diagnosis of the index CRC (SHR = 2.20, 95% CI: 1.20–4.03), and a reduction in or loss of MMR protein expression (SHR = 2.07, 95% CI: 1.04–4.13) were significantly associated with the risk of MPC in individuals diagnosed with an index CRC (Table 2).