For instance, the positive correlation between ENHO and CD27, along with the negative correlation with its ligand CD70, suggests a protective immune response driven by ENHO, even as tumor strategies, such as upregulating immune checkpoints like PD-1 and LAG3 or suppression of MHC-I antigen presentation via the downregulation of TAP1, TAP2, and TAPBP, counterbalance this effect. Here, LAG3 is linked to neoplasm.