TAP1 and pancreatic adenocarcinoma: Although Xiao et al. reported that TAP1 and TAP2 are consistently upregulated in interferon-gamma-dominant PAAD subtypes, underscoring their role in MHC-1 antigen loading and presentation to cytotoxic T-cells [34], the analysis emphasized the downregulation of TAP1 and TAP2 as a tumor-mediated strategy for immune evasion.