Further workup by Leslie et al. on a syngeneic mouse model in an attempt to show the effect of histone deacetylase 11 (HDAC11) on lymph node dissemination revealed that the inhibition of HDAC 11 might decrease intranodal tumor cell proliferation but paradoxically substantially increases migration of breast cancer cells from the lymph node to the lung [136]. This evidence concerns the gene HDAC11 and neoplasm.