PDPN and neoplasm: Recent evidence suggests that lymphatic vascular biomarkers such as the Vascular Endothelial Growth Factor (VEGF)-R3, LYVE-1, podoplanin, and Prox-1 (prospero-related homeobox-1) play crucial roles in promoting lymphangiogenesis and facilitating tumor dissemination to axillary lymph nodes [13,14].