The expression of each marker gene was shown in Figure 1D. We identified two clusters of macrophages/DCs (MSR1, C1QC, FOLR2), six clusters of osteoblastic tumor cells (SATB2, IBSP, ALPL), one cluster of natural killer (NK) and T cells (CD3D, NKG7, TRBC1), osteoclasts (ACP5, CTSK, MMP9), monocytes/neutrophils (S100A8, S100A9, FCN1), fibroblasts (TAGLN, ACTA2, FAP), B-cells (MS4A1, CD79A, BANK1), plasma cells (IGHG1, IGLC2, IGHG4), mast cells (TPSB2, TPSAB1, CPA3), and endothelial cells (CLEC14A, PLVAP, VWF). The gene discussed is IGHG1; the disease is neoplasm.