SPN and B-cell chronic lymphocytic leukemia: Additionally, SPN expression was higher in CLL patients, as well as Ps patients, compared to HVs (1706 vs. 82.24 p < 0.0001), (451.8 vs. 82.24 p < 0.0001), respectively, and SPN expression was higher in CLL patients compared to Ps patients (1706 vs. 451.8 p < 0.0001) (Figure 1c).