We showed statistically significant, positive correlations between expressions of the following pairs of genes, including SPN and CD160 (r = 0.7822, p < 0.0001), SPN and BTA (r = 0.7960, p < 0.0001), SPN and TIGIT (r = 0.6800, p < 0.0001), CD160 and TIM3 (r = 0.6212, p < 0.0001), and BTLA and TIGT (r = 0.6774, p < 0.0001), as well as TIM3 and VISTA (r = 0.6331, p < 0.0001), in CLL (Figure 2a–f). This evidence concerns the gene SPN and B-cell chronic lymphocytic leukemia.