Additionally, we provided statistically significant correlations between expressions of the following genes with the most statistical significance for paired genes, including SPN and CD160, SPN and BTLA, SPN and TIGIT, CD160 and TIM3, BTLA and TIGT and TIM3 and VISTA in CLL, and for SPN and TIGT, SPN and TIM3, SPN and BTLA, SPN and CD160, CD160 and TIM3, CD160 and TIGIT in Ps. The gene discussed is TIGIT; the disease is B-cell chronic lymphocytic leukemia.