Higher expression of TIGIT was observed in CLL groups with stages 1 and 2, compared to stage 0, according to the Rai classification (806.3 vs. 500.6, p = 0.0263), as well as in CLL groups in stages 1,2,3 and 4, compared to stage 0 (647.4 vs. 500.6, p = 0.0300) (Figure 4d). This evidence concerns the gene TIGIT and B-cell chronic lymphocytic leukemia.