Therefore, the current study aimed to present a collective expression pattern of crucial immuno-regulatory genes including BTLA, CD160, SPN, TIM-3, VISTA and TIGIT on the mRNA level, as well as perform a comparison with two different diseases, CLL and Ps, referring to recognized prognostic markers as well as clinical characteristics. The gene discussed is BTLA; the disease is B-cell chronic lymphocytic leukemia.