The most common correlations between mutations and associated tumors are between BRCA1 and BRCA2 and breast, ovarian, prostate, and pancreatic cancer; between APC and colorectal cancer (Familial Adenomatous Polyposis—FAP); between MLH1, MSH2, MSH6, and PMS2 and colorectal and endometrial cancer (Lynch syndrome). This evidence concerns the gene PMS2 and Familial adenomatous polyposis.