In every recent AML classification system, ranging from the one comprising 13 subgroups proposed by Papaemmanuil E et al. in 2016 [24] to the newest involving 16 distinct subgroups suggested by Tazi Y et al. in 2022 [29], AML with the NPM1 mutation is classified as a separate category. The gene discussed is NPM1; the disease is acute myeloid leukemia.