SEMA7A is known to belong to a SEMA7A-integrin-β1 axis that activates Mitogen-Activated Protein Kinase (MAPK) cascades, especially the ERK/MAPK signaling pathway, which plays crucial role in regulating oncogenic functions, including metastasis and tumor progression [36,37,38,39]. Here, SEMA7A is linked to neoplasm.