This epidermal-to-dermal signaling axis is reinforced by our finding that chronic TGFβ treatment, a hallmark of advanced tumor microenvironments, upregulates IL19 in fibroblasts (Figure 3G), suggesting a feedforward loop where stromal IL19 further amplifies TOPK activity in adjacent tumor cells (Figure 3F). Here, TGFB1 is linked to neoplasm.