The pathogenesis of Alzheimer’s disease is modulated by APOE status [61,62] and other genetic factors [63,64,65,66,67]; a range of cardiovascular risk factors [68,69,70,71]; and lifestyle [72,73,74,75,76,77,78,79,80,81,82] and environmental risk factors [83,84,85]. The gene discussed is APOE; the disease is Alzheimer disease.