The OR for stroke (OR = 3.288, 95% CI: 1.760–6.216) was substantially higher than that for heart disease (OR = 1.679, 95% CI: 1.092–2.257), suggesting that the combination of insulin resistance and adiposity captured by TyG-RFM may exert a particularly potent detrimental effect on the cerebral vasculature. The gene discussed is INS; the disease is stroke disorder.