DDIT3 and metabolic dysfunction-associated steatohepatitis: These effects are achieved through the downregulation of protein kinase RNA-like endoplasmic reticulum kinase (PERK) and C/EBP homologous protein (CHOP) expression, the restoration of Beclin-1 levels, and the improvement of the ratio between Bcl-2-associated X protein (Bax)/B-cell lymphoma 2 protein (Bcl-2) in HFD-induced MASH model mice [124].