Ob-NAFLD is characterized by hepatic lipid accumulation, lipotoxicity, and hepatic inflammation, all of which elevate systemic levels of pro-inflammatory cytokines such as tumor necrosis factor-α (TNF-α) and monocyte chemoattractant protein (MCP-1) [8,9,10,11,12]. This evidence concerns the gene CCL2 and metabolic dysfunction-associated steatotic liver disease.