PHLPP2 and Hyperglycemia: This suppression may result from multiple mechanisms: hyperglycemia-induced disruption of the liver kinase B1 (LKB1) complex [32], activation of protein phosphatase PP2A [33], upregulation of PH domain and leucine-rich repeat protein phosphatase 2 (PHLPP2) [34], and ubiquitin-mediated degradation of AMPK subunits [35,36].