The top 10 pathways were screened out (Figure 5), which were the PI3K-Akt pathway, Lipid and atherosclerosis, Proteoglycans in cancer, Chemical carcinogenesis—receptor activation, Chemical carcinogenesis—reactive oxygen species, Human cytomegalovirus infection, Kaposi sarcoma-associated herpesvirus infection, Prostate cancer, Fluid shear stress and atherosclerosis, and EGFR tyrosine kinase inhibitor resistance. The gene discussed is AKT1; the disease is atherosclerosis.