The antitumor effect of SH on HepG2 cells was significantly stronger (IC50 = 5.07%) than that of carbohydrate components (IC50 = 9.60%~16.24%), of which the mechanism was seen in various pathways, PI3K-Akt, Lipid and atherosclerosis, Proteoglycans in cancer, Chemical carcinogenesis—receptor activation, and Chemical carcinogenesis—reactive oxygen species pathways, through network pharmacology analysis. This evidence concerns the gene AKT1 and cancer.