Cyclical eating patterns (feast or famine) can generate disrupted eating schedules (e.g., overeating when food is available and undereating when food is unavailable), which contribute to metabolic stress, insulin resistance, blood pressure fluctuation, chronic stress, and coping mechanisms (HPA Axis Stimulation) and can create psychosocial stress, which is a risk factor in itself for cardiovascular disease. The gene discussed is INS; the disease is cardiovascular disorder.