Compared to the CK3 group, the significant differential metabolic pathways in the T3 group were glyoxylate and dicarboxylate metabolism, a glucagon signaling pathway, citrate cycle (TCA cycle), carbon metabolism, central carbon metabolism in cancer, purine metabolism, amino acid metabolism, fructose and manmose metabolism, inositol phosphate metabolism, etc. (Figure 5K). The gene discussed is GCG; the disease is cancer.