Alzheimer’s disease (AD) is a neurodegenerative disorder, characterized by a highly complex and varied pathophysiology involving the buildup of senile plaques formed by amyloid beta (Aβ) peptide deposited outside cells and the presence of intraneurofibrillary tangles (NFTs) produced from abnormally phosphorylated tau protein (pTau) [51]. Here, MAPT is linked to Alzheimer disease.