For example, ALKBH1, which has been implicated in gastric cancer and glioblastoma, has the potential to induce mitochondrial damage by targeting N6-methyladenine (N6mA) in DNA and exerting its demethylase activity, thereby downregulating and disrupting genes encoded by mitochondrial DNA [11]. The gene discussed is ALKBH1; the disease is glioblastoma.