To examine whether macrophages regulate mucus secretion from goblet cells in the absence of SLAMF7, which may in turn affect susceptibility to colitis, we intraperitoneally injected WT and slamf7-/- mice with clodronate liposomes (neutral) to deplete colonic macrophages and then supplemented the treatment with DSS (Figure 4(g)). This evidence concerns the gene SLAMF7 and colitis.