IL10 and colitis: We then challenged these slamf7-/- mice with DSS and found that blocking IL-10 and TGF-β aggravated DSS-induced colitis, as the weight loss (Figure S9h), DAI score (Figure S9i), colon length (Figure S9j,k), and goblet cell number (Figure S9l,m) of these mice were similar to those of WT mice.