SH2D1A and plasma cell myeloma: It has been reported that SLAMF family protein self-engagement transduces positive signals by recruiting a family of adaptors, including SLAM-associated protein (SAP), SHP-1 and/or SHP-2.59 SLAMF7 self-engagement activates the SHP-2 signaling pathway in myeloma cells.60 Although we observed that SLAMF7 depletion decreased SHP-2 in macrophages, further studies are necessary to elucidate the molecular mechanism underlying this phenomenon.