This process increases NK cell-mediated cytotoxicity and triggers the release of IFN-γ, TNF-α, and granzymes, leading to the targeted destruction of myeloma cells through apoptosis.53 Our findings suggest that SLAMF7 activation drives intestinal inflammation by decreasing C1q+ M2-like macrophages and downregulating their associated cytokines, IL-10 and TGF-β, via the SLAMF7-SHP2-STAT6 pathway in the gut. Here, TNF is linked to plasma cell myeloma.