SLAMF7 and keratitis: Previous studies have shown that SLAMF7 suppresses the inflammatory response in murine models of sepsis and keratitis and that SLAMF7-knockout mice exhibit more severe tissue damage than do WT mice.16,17 However, in other contexts, activation of the SLAMF7 receptor in macrophages leads to rapid and extensive production of inflammatory cytokines and chemokines.