Results showed that SCH772984 efficiently reversed APPLE-induced ERK1/2 phosphorylation (Fig. 6A), decreased the elevated expression levels of AFP (Fig. 6B) and PCNA (Fig. 6C), and inhibited APPLE-mediated proliferation, migration, and invasion of HCC cells (Fig. 6D-G). The gene discussed is PCNA; the disease is hepatocellular carcinoma.