In PEO4, many signalling pathways were enriched amongst downregulated genes, including Hippo, WNT, MAPK, and TGF-B (Fig. 5E); all of which are implicated in the control of EMT, responses to stress and are reported to contribute to acquired drug tolerance in ovarian cancer [55, 80, 81]. The gene discussed is TGFB1; the disease is ovarian cancer.