While the GWAS Catalog did not report associations between C11orf54 and metabolic phenotypes, several genetic variants in RARB have been linked to metabolic traits: rs1435703 was associated with obesity (GCST000426), rs76532059 with fasting insulin levels in childhood (GCST90310278), rs138514634 with abdominal fat cell number (GCST90104785), and rs322699 with abdominal fat distribution (GCST90020028). This evidence concerns the gene INS and obesity due to melanocortin 4 receptor deficiency.