We also conducted a search in the EWAS Catalog and EWAS Atlas that showed that DNAm of both genes has been already associated with relevant metabolic traits such as insulin resistance for C11orf54 and several metabolic traits like obesity, incident and prevalent T2D, lipids concentrations and non-alcoholic fatty liver disease for RARB, as extensively reported in Table S5. This evidence concerns the gene RARB and obesity due to melanocortin 4 receptor deficiency.