Fasting plasma maternal insulin levels at 18-20gw in pregnant mothers with obesity were associated with both the abdominal/total FMr in newborns and cord blood DNAm at two sites annotated to RARB and C11orf54 genes after adjustment for multiple maternal metabolic risk factors and potential confounders. This evidence concerns the gene BKGD and obesity due to melanocortin 4 receptor deficiency.