INS and Obesity: While the GWAS Catalog did not report associations between C11orf54 and metabolic phenotypes, several genetic variants in RARB have been linked to metabolic traits: rs1435703 was associated with obesity (GCST000426), rs76532059 with fasting insulin levels in childhood (GCST90310278), rs138514634 with abdominal fat cell number (GCST90104785), and rs322699 with abdominal fat distribution (GCST90020028).