In 95 of 108 subjects that also had CSF AD biomarkers done at Mayo Clinic Laboratories, we observed highly significant positive correlations between 71A1/3D6 signals and both total tau (311.3 ± 190.9 pg/mL) (r = 0.66, p < 0.0001) and phosho-T181) (30.7 ± 19.9 pg/mL) (r = 0.68, p < 0.0001; Pearson correlation coefficients) in the same CSFs (Fig. 6A, B). Here, MAPT is linked to Alzheimer disease.