The results of Elisa assay (Fig. 3E) further confirmed that the secretion of CXCL12 in Mut-MSCs was also significantly higher than that in the MSCs cells, and the above results suggested that we could target Mut-MSCs of MPN model through the interactions such as CXCR4/CXCL12. The gene discussed is CXCR4; the disease is myeloproliferative neoplasm.